Key result
A Sabin 3/Sabin 2/Sabin 3 intertypic recombinant poliovirus isolated from a healthy 2-year-old boy 12 weeks post-vaccination showed chimeric capsid proteins but retained Sabin 3 antigenic features.
Population
Recombinant poliovirus isolated from a faecal specimen of a 2-year-old healthy boy 12 weeks post-oral…
Comparison
Genomic and antigenic characterization of the… vs Parental Sabin strains (Sabin 3).
Design
Preclinical
Authors
Loading...
Reassures that intra-host Sabin recombination preserves antigenicity and neutralization susceptibility; leaves open prevalence and risk in OPV recipients.
Case Report (n=1)
The chimeric poliovirus was likely generated by recombination events in the vaccinee rather than representing circulating vaccine-derived virus, and it remains susceptible to neutralization by vaccine-induced antibodies.
Blomqvist et al. (2003) conducted a case report in Healthy vaccinee (n=1). Oral poliovirus vaccine was evaluated on Genomic and antigenic characterization of the isolated recombinant poliovirus. A Sabin 3/Sabin 2/Sabin 3 intertypic recombinant poliovirus isolated from a healthy 2-year-old boy 12 weeks post-vaccination showed chimeric capsid proteins but retained Sabin 3 antigenic features.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: