Key result
Human intestinal Caco-2 cells cured of persistent poliovirus infection demonstrated partial resistance to apoptosis compared to parental cells.
Persistent poliovirus infection in human intestinal cells may select for cells that are partially resistant to apoptosis.
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May select apoptosis-resistant clones during persistent infection; leaves open relevance to human poliovirus pathogenesis.
Cells cured of persistent virus infection can be used to investigate cellular pathways of resistance to viral cytopathic effects. Persistent poliovirus (PV) infections were established in human intestinal Caco-2 cells, and spontaneously cured cell cultures were obtained. Two cell clones, cl6 and b13, cured of type 3 PV mutant infection and their parental Caco-2 cells were compared for susceptibility to PV infection, PV receptor CD155 expression, capacity to differentiate into polarized enterocytes, and PV-, staurosporine-, and actinomycin D-induced apoptosis. Our results strongly suggest that cells that are partially resistant to apoptosis can be selected during persistent virus infection.
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Labadie et al. (2006) studied Persistent poliovirus infection. Curing of persistent poliovirus infection (cell clones cl6 and b13) vs. Parental Caco-2 cells was evaluated on Susceptibility to PV infection, PV receptor CD155 expression, capacity to differentiate, and apoptosis. Human intestinal Caco-2 cells cured of persistent poliovirus infection demonstrated partial resistance to apoptosis compared to parental cells.
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