Key result
Tat protein mediates the specific adenosine-to-inosine modification of wild-type HIV-1 TAR RNA by a double-stranded RNA-modifying activity in the nucleus of Xenopus oocytes.
Tat-dependent adenosine-to-inosine modification of TAR RNA by dsRNA-modifying activity in the nucleus may play a role in HIV-1 expression.
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May support HIV RNA editing studies; leaves open relevance to human viral replication or therapy.
Sharmeen et al. (1991) studied HIV-1 (basic science model). Tat protein and TAR RNA microinjection vs. Absence of Tat or mutant TAR RNA was evaluated on Adenosine-to-inosine modification of TAR RNA. Tat protein mediates the specific adenosine-to-inosine modification of wild-type HIV-1 TAR RNA by a double-stranded RNA-modifying activity in the nucleus of Xenopus oocytes.
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