August 1, 1990Genes & DevelopmentOpen Access

A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation.

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Population

In vitro models of HIV-1 TAR RNA and Tat protein

Comparison

Mutations in TAR RNA vs Wild-type TAR RNA

Design

Preclinical

Authors

SRSophie RoyBristol-Myers Squibb (Germany)UDUlrike DellingCincinnati Children's Hospital Medical Center CCC H ChenMcGill University

Discussion

Member takes

Implication

May guide TAR-targeted antivirals; leaves open validation in cellular and animal HIV models.

Structured PICO

Population

In vitro models of HIV-1 TAR RNA and Tat protein

Intervention

Mutations in TAR RNA (3-nucleotide bulge structure, single base substitutions, loop mutations, stem mutations)

Comparator

Wild-type TAR RNA

Outcome

Tat binding to TAR RNA and Tat-mediated trans-activationsurrogate

Identifies the specific 3-nucleotide bulge in HIV-1 TAR RNA required for Tat binding and trans-activation, providing mechanistic insights into viral replication.

Cite This Study

Roy et al. (1990) studied this question.

synapsesocial.com/papers/6a6fcf5c87f92105712754b7 https://doi.org/10.1101/gad.4.8.1365

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A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider