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July 15, 1991Proceedings of the National Academy of SciencesOpen Access

The number of positively charged amino acids in the basic domain of Tat is critical for trans-activation and complex formation with TAR RNA.

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Population

In vitro and in vivo models studying HIV Tat protein and TAR RNA

Comparison

Peptide derivatives of Tat and homopolymers of… vs Wild-type Tat and mutant TAR RNA

Design

Preclinical

Authors

UDUlrike DellingCincinnati Children's Hospital Medical CenterSRSophie RoyBristol-Myers Squibb (Germany)MSMartin Sumner-SmithUniversity of Toronto

Discussion

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Implication

Arginine motifs in Tat may inform antiviral peptide design; hypothesis-generating for HIV research and should not yet change practice.

Structured PICO

P
Population
In vitro and in vivo models studying HIV Tat protein and TAR RNA
I
Intervention
Peptide derivatives of Tat and homopolymers of arginine substituting for the basic domain
C
Comparator
Wild-type Tat and mutant TAR RNA
O
Outcome
Trans-activation of viral gene expression and complex formation with TAR RNAsurrogate

The number of positively charged amino acids (arginines) in the basic domain of Tat is critical for its binding to TAR RNA and subsequent trans-activation.

Cite This Study

Delling et al. (1991) studied this question.

synapsesocial.com/papers/6a715f6d6c240de38cdc1caahttps://doi.org/10.1073/pnas.88.14.6234
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat1988 · 236 citations
  2. 2<i>Trans</i> -Acting Transcriptional Regulation of Human T-Cell Leukemia Virus Type III Long Terminal Repeat1985 · 501 citations
  3. 3A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat.1990 · 96 citations
  4. 4Specific binding of a HeLa cell nuclear protein to RNA sequences in the human immunodeficiency virus transactivating region.1989 · 120 citations