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April 1, 1992Journal of VirologyOpen Access

Functional comparison of the basic domains of the Tat proteins of human immunodeficiency virus types 1 and 2 in trans activation

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Population

In vitro models studying HIV-1 and HIV-2 Tat proteins

Comparison

Domain substitution between Tat1 and Tat2 vs Wild-type Tat1 and Tat2

Design

Preclinical

Authors

TST. SubramanianChennai Mathematical InstituteGCG. ChinnaduraiSacred Heart College

Discussion

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Implication

Basic domain dictates Tat transactivation potency; leaves open its contribution to HIV-1/HIV-2 replication differences in vivo.

Structured PICO

P
Population
In vitro models studying HIV-1 and HIV-2 Tat proteins
I
Intervention
Domain substitution between Tat1 and Tat2 (exchanging basic domains)
C
Comparator
Wild-type Tat1 and Tat2
O
Outcome
Trans activation of the HIV-1 long terminal repeat (LTR)surrogate

The basic domain of HIV-2 Tat contributes to its inefficient trans activation of the HIV-1 LTR, partially due to an adjacent acidic residue.

Cite This Study

Subramanian et al. (1992) studied this question.

synapsesocial.com/papers/6a9775e238c443675e62dd2ahttps://doi.org/10.1128/jvi.66.4.2031-2036.1992
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Functional analysis of the Tat trans activator of human immunodeficiency virus type 21989 · 67 citations
  2. 2Fragments of the HIV-1 Tat Protein Specifically Biand TAR RNA1990 · 451 citations