Key result
Alpha-skeletal actin mRNA increases during human development to become the predominant isoform in normal adult hearts (60.4%), and this proportion remains unchanged in adult failing hearts (62.84%).
Population
Ventricles from 36 human subjects: 21 control patients and 15 adult patients undergoing cardiac…
Design
Other
Authors
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Challenges fetal gene program reactivation for actin in heart failure; extends developmental expression data to adult disease.
Observational (n=36)
Yes
Absolute Event Rate: 62.84% vs 60.4%
In human hearts, alpha-skeletal actin mRNA expression increases during development to become the predominant isoform in adults, and this pattern is maintained in hypertrophied and failing hearts.
Boheler et al. (1991) conducted an observational in Normal cardiac development and end-stage heart failure (n=36). End-stage heart failure vs. Normal adult hearts was evaluated on Proportion of alpha-skeletal actin mRNA relative to total sarcomeric actin mRNA. Alpha-skeletal actin mRNA increases during human development to become the predominant isoform in normal adult hearts (60.4%), and this proportion remains unchanged in adult failing hearts (62.84%).
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