Key result
An artificial muscle device tested in a bench model of a diseased heart generated a systolic pressure of 75 mm Hg, ejected a maximum of 330 ml/min, and achieved an ejection fraction of 12%.
Why the study?
Does an artificial muscle device generate effective hemodynamic assistance in a bench model of a diseased heart?
Does an artificial muscle device generate effective hemodynamic assistance in a bench model of a diseased heart?
A novel artificial muscle device demonstrated feasibility in generating systolic pressure and ejection fraction in a bench model, suggesting early proof-of-concept for future heart assist devices.
Answers are grounded in this paper and cite their sources.
Bench feasibility does not support clinical use; leaves open translation of artificial muscle to in vivo HF models.
We describe a device made of artificial muscle for the treatment of end-stage heart failure as an alternative to current heart assist devices. The key component is a matrix of nitinol wires and aramidic fibers called Biometal muscle (BM). When heated electrically, it produces a motorless, smooth, and lifelike motion. The BM is connected to a carbon fiber scaffold, tightening the heart and providing simultaneous assistance to the left and right ventricles. A pacemaker-like microprocessor drives the contraction of the BM. We tested the device in a dedicated bench model of diseased heart. It generated a systolic pressure of 75 mm Hg and ejected a maximum of 330 ml/min, with an ejection fraction of 12%. The device required a power supply of 6 V, 250 mA. This could be the beginning of an era in which BMs integrate or replace the mechanical function of natural muscles.
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Tozzi et al. (2012) studied End-stage heart failure. Artificial muscle device (Biometal muscle) was evaluated on Hemodynamic performance in a bench model. An artificial muscle device tested in a bench model of a diseased heart generated a systolic pressure of 75 mm Hg, ejected a maximum of 330 ml/min, and achieved an ejection fraction of 12%.
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