Key result
Higher perceived social disability is linked to greater left angular gyrus activation to sad faces.
Why the study?
To determine whether social dysfunction across depressive and anxiety disorders is coupled to altered neural processing of valenced emotional stimuli and whether a common neurobiological correlate exists.
Does social dysfunction correlate with altered neural processing of emotional stimuli across depressive and anxiety disorders?
Population
Participants with depression (N = 46), anxiety (N = 45), comorbid depression and anxiety (N = 57), and healthy controls (N = 52)
Comparison
Depression vs anxiety vs comorbid depression and anxiety vs healthy controls
Design
Cross-sectional fMRI study
Authors
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Links social disability to angular gyrus response to sadness; hypothesis-generating for transdiagnostic mechanisms, needs longitudinal confirmation.
Cross-Sectional (n=200)
Does social dysfunction correlate with altered neural processing of emotional stimuli across depressive and anxiety disorders?
Perceived social disability correlates with increased left angular gyrus activation during sad emotional processing across individuals with and without depressive or anxiety disorders.
Braak et al. (2024) conducted a cross-sectional in Depressive and anxiety disorders (n=200). Perceived social disability and loneliness was evaluated on Brain activation in response to emotional stimuli (implicit emotional faces fMRI task). Higher perceived social disability across persons with and without depressive or anxiety disorders was associated with greater brain activation in the left angular gyrus to sad emotional faces.
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