Key result
Frequent aPTT measurements (≥2) after dabigatran initiation did not significantly reduce the discontinuation rate (15% vs 17%) or incidence of bleeding (3% vs 5%) compared to a single measurement.
Why the study?
Does frequent aPTT measurement reduce adverse clinical events in patients with non-valvular atrial fibrillation after dabigatran initiation?
Cohort (n=380)
Yes
Does frequent aPTT measurement reduce adverse clinical events in patients with non-valvular atrial fibrillation after dabigatran initiation?
Absolute Event Rate: 15% vs 17%
p-value: p=not significant
Frequent aPTT measurements after dabigatran initiation do not appear to reduce adverse clinical events such as bleeding or drug discontinuation compared to infrequent measurements.
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Frequent aPTT monitoring after dabigatran was not associated with fewer events; leaves open whether routine checks improve outcomes in NVAF.
Yamashita et al. (2014) conducted a cohort in non-valvular atrial fibrillation (NVAF) (n=380). Frequent aPTT measurements (≥2 measurements) vs. Infrequent aPTT measurements (1 measurement) was evaluated on discontinuation rate (p=not significant). Frequent aPTT measurements (≥2) after dabigatran initiation did not significantly reduce the discontinuation rate (15% vs 17%) or incidence of bleeding (3% vs 5%) compared to a single measurement.
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