Key result
Among patients with panic disorder or agoraphobia, 34% had definite mitral valve prolapse and 5% had a probable diagnosis based on clinical and echocardiographic findings.
Cross-Sectional (n=131)
A high prevalence of mitral valve prolapse (34% definite, 5% probable) was found in patients with panic disorder or agoraphobia, confirming previous reports of this association.
Association warrants clinical awareness in panic disorder; confirms prior links but leaves open causality and practice implications.
Of 131 patients with panic disorder or agoraphobia, 44 (34%) had definite mitral valve prolapse on the basis of clinical findings of an apical mid- or late systolic click and a murmur and/or a two-dimensional echocardiogram showing prolapse of one leaflet in two views or of two leaflets in a single view. Seven other patients (5%) had a probable diagnosis of mitral prolapse on the basis of a typical murmur alone or an intermittent apical mid- or late systolic click and a prolapsing leaflet in a single echocardiographic view. This finding confirms previous reports of the association between panic disorder and mitral valve prolapse.
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Liberthson et al. (1986) conducted a cross-sectional in Panic disorder or agoraphobia (n=131). Panic disorder or agoraphobia was evaluated on Definite mitral valve prolapse. Among patients with panic disorder or agoraphobia, 34% had definite mitral valve prolapse and 5% had a probable diagnosis based on clinical and echocardiographic findings.
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