Key result
Mitral valve prolapse was not associated with a significantly higher prevalence of panic disorder compared to cardiac controls (12.1% vs 3.7%, NS).
Why the study?
Is mitral valve prolapse associated with a higher prevalence of panic disorder compared to other minor cardiac abnormalities?
Observational (n=60)
Single-blind
Is mitral valve prolapse associated with a higher prevalence of panic disorder compared to other minor cardiac abnormalities?
Absolute Event Rate: 12.1% vs 3.7%
p-value: p=NS
The study found no significant difference in the prevalence of panic disorder between patients with mitral valve prolapse and a cardiac control group, arguing against a special causal relationship.
No link between mitral valve prolapse and panic disorder versus other cardiac issues; leaves open whether earlier associations reflected confounding.
This study investigated the relationship between mitral valve prolapse (MVP) and panic disorder (PD), by comparing the prevalence of PD in 33 patients with MVP and 27 patients with haemodynamically insignificant atrial septal defect or patent ductus arteriosus. MVP was diagnosed using standard echocardiographic criteria and the presence of mental disorder was assessed blindly with the help of the Schedule for Affective Disorders and Schizophrenia. DSM-III criteria were used to diagnose PD. The two groups did not differ in age and sex; 12.1% of MVP patients and 3.7% of cardiac controls had PD (NS). Although the prevalence of PD in our sample of MVP patients was considerably higher than the prevalence of PD in the general population, this need not necessarily indicate a causal relationship between MVP and PD and may be due to studying a hospital-based sample. The absence of any significant difference in prevalence of PD between MVP patients and a carefully selected cardiac control group drawn from the same setting argues against any special relationship between PD and MVP.
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Sivaramakrishnan et al. (1994) conducted an observational in Mitral valve prolapse and panic disorder (n=60). Mitral valve prolapse vs. Haemodynamically insignificant atrial septal defect or patent ductus arteriosus was evaluated on Prevalence of panic disorder (p=NS). Mitral valve prolapse was not associated with a significantly higher prevalence of panic disorder compared to cardiac controls (12.1% vs 3.7%, NS).
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