Key result
The incidence of mitral valve prolapse was 32.2% in panic disorder patients vs 16.7% in controls (NS), but was significantly higher in PD patients with depression (58.1%) than without (25.7%).
Why the study?
Is panic disorder associated with a higher incidence of mitral valve prolapse and altered autonomic function compared to healthy controls?
Population
121 patients diagnosed with panic disorder (PD) and healthy controls
Comparison
Panic disorder (with or without depression) vs Healthy controls
Design
Case-control
Authors
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MVP may be more frequent in panic disorder with comorbid depression; hypothesis-generating and requires prospective confirmation before clinical consideration.
Case-Control (n=121)
Is panic disorder associated with a higher incidence of mitral valve prolapse and altered autonomic function compared to healthy controls?
Absolute Event Rate: 32.2% vs 16.7%
p-value: p=not significant
Panic disorder, particularly when accompanied by depression, is associated with a higher rate of mitral valve prolapse and reduced parasympathetic nervous system activity.
Hamada et al. (1998) conducted a case-control in Panic disorder (n=121). Panic disorder vs. Healthy controls was evaluated on Incidence of mitral valve prolapse (p=not significant). The incidence of mitral valve prolapse was 32.2% in panic disorder patients vs 16.7% in controls (NS), but was significantly higher in PD patients with depression (58.1%) than without (25.7%).
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