Key result
Bretylium tosylate rendered a young woman with familial Q-T prolongation syndrome and recurrent convulsive seizures free of symptoms.
Why the study?
Does bretylium tosylate improve symptoms in a patient with familial Q-T prolongation syndrome and recurrent convulsive seizures?
Case Report (n=1)
Does bretylium tosylate improve symptoms in a patient with familial Q-T prolongation syndrome and recurrent convulsive seizures?
Bretylium tosylate successfully treated recurrent convulsive seizures and paroxysmal ventricular fibrillation in a patient with familial Q-T prolongation syndrome.
May control symptoms in familial long QT with seizures; single case leaves open need for controlled trials.
A young woman with familial prolongation of the Q-T interval had recurrent convulsive seizures associated with episodes of paroxysmal ventricular fibrillation. Although this potentially fatal disorder is difficult to treat, bretylium tosylate rendered the patient free of symptoms. The recognition of convulsive seizures as the presenting sign in this syndrome is of great importance, for only detailed electrocardiographic study will enable the physician to make the correct diagnosis and search for effective treatment.
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Philip A. Singer (1974) conducted a case report in Familial prolongation of the Q-T interval (n=1). Bretylium tosylate was evaluated on Symptom resolution. Bretylium tosylate rendered a young woman with familial Q-T prolongation syndrome and recurrent convulsive seizures free of symptoms.
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