Positive coronary arterial remodeling, measured by mean coronary cross-sectional area, was inversely correlated with CD4+ T-cell count (ρ=-0.2, P=0.047) and plasma IL-10 (ρ=-0.25, P=0.03).
Cross-Sectional (n=105)
Does coronary cross-sectional area measured by noncontrast CT correlate with cardiovascular risk and HIV-related factors in virally suppressed persons with HIV?
Positive coronary arterial remodeling assessed by noncontrast CT is associated with lower CD4 T-cell count and lower IL-10 in persons with HIV, suggesting its utility as an imaging marker of subclinical atherosclerosis.
Estimación del efecto: ρ=-0.2
valor p: p=0.047
Background Persons with HIV have a higher prevalence of coronary artery disease compared with their HIV‐negative counterparts. Earlier identification of subclinical atherosclerosis may provide a greater opportunity for cardiovascular disease risk reduction. We investigated coronary cross‐sectional area (CorCSA) by noncontrasted computed tomography imaging as a noninvasive measure of arterial remodeling among virally suppressed persons with HIV. Methods and Results We assessed 105 persons with HIV with a spectrum of cardiometabolic health. All participants underwent computed tomography imaging to assess the mean corCSA of the proximal left anterior descending artery and 28 participants underwent additional coronary computed tomography angiography. Partial Spearman rank correlations adjusted for cardiovascular disease risk factors were used to assess relationships of corCSA with anthropometric measurements, HIV‐related factors, and plasma cytokines. Mean corCSA measured by noncontrast computed tomography and coronary computed tomography angiography were strongly correlated (ρ=0.91, P <0.0001). Higher mean corCSA was present in those with coronary artery calcium ( P =0.005) and it correlated with participants' atherosclerotic cardiovascular disease risk score (ρ=0.35, P =0.01). After adjusting for established cardiovascular disease risk factors, we observed an inverse relationship between corCSA and CD4 + T‐cell count (ρ=−0.2, P =0.047). Removal of age from the model strengthened the relationships between corCSA and antiretroviral therapy duration (from ρ=0.19, P =0.08 to ρ=0.3, P =0.01). CorCSA was also inversely correlated with plasma IL‐10 (ρ=−0.25, P =0.03) but had no relationship with IL‐6 (ρ=0.11, P =0.4) or IL‐1β (ρ=0.08, P =0.5). Conclusions Positive coronary arterial remodeling, an imaging marker of subclinical atherosclerosis, is associated with a lower CD4 T‐cell count, lower circulating IL‐10, and possibly a longer antiretroviral therapy duration in persons with HIV. Registration Clinicaltrials.gov; Unique identifier: NCT04451980.
Werede et al. (Wed,) conducted a cross-sectional in HIV (n=105). CD4+ T-cell count and plasma IL-10 was evaluated on Mean coronary cross-sectional area (corCSA) (ρ=-0.2, p=0.047). Positive coronary arterial remodeling, measured by mean coronary cross-sectional area, was inversely correlated with CD4+ T-cell count (ρ=-0.2, P=0.047) and plasma IL-10 (ρ=-0.25, P=0.03).