Why the study?
Does high glucose concentration alter ANG II receptor regulation and PKC isoform translocation in rat mesangial cells compared to normal glucose?
Does high glucose concentration alter ANG II receptor regulation and PKC isoform translocation in rat mesangial cells compared to normal glucose?
High glucose concentrations downregulate AT1 receptors and alter PKC isoform translocation in rat mesangial cells, providing insight into cellular mechanisms under diabetic conditions.
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Altered mesangial ANG II signaling under hyperglycemia is hypothesis-generating; leaves open its contribution to diabetic nephropathy in vivo.
Amiri et al. (1999) studied this question.
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