August 1, 2001DiabetesOpen Access

Angiotensin II Promotes Glucose-Induced Activation of Cardiac Protein Kinase C Isozymes and Phosphorylation of Troponin I

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Population

Primary cultures of adult rat ventricular myocytes

Comparison

High glucose exposure for 12-24 h, with or… vs Normal glucose (5 mmol/l) exposure

Design

Preclinical

Follow-up

12-24 h

Authors

AMAshwani MalhotraAlbert Einstein College of Medicine BKBarinder KangRutgers, The State University of New Jersey SCSimon CheungVancouver General Hospital

Discussion

Member takes

Implication

May link hyperglycemia to myocyte PKC activation via autocrine Ang II; hypothesis-generating for diabetic cardiomyopathy mechanisms.

Structured PICO

Population

Primary cultures of adult rat ventricular myocytes

Intervention

High glucose (25 mmol/l) exposure for 12-24 h, with or without inhibitors (tricyclodecan-9-yl-xanthogenate, genistein, 1,2-bis(2-aminophenoxy)ethane N,N,N,'N'-tetraacetic acid, losartan 100 nmol/l)

Comparator

Normal glucose (5 mmol/l) exposure

Outcome

Translocation of PKC isozymes, ANG II release, and phosphorylation of troponin Isurrogate

High glucose induces autocrine release of Angiotensin II in ventricular myocytes, leading to AT-1R-dependent PKC activation and troponin I phosphorylation, suggesting a mechanism for diabetic cardiomyopathy.

Cite This Study

Malhotra et al. (2001) studied this question.

synapsesocial.com/papers/6a75afcbd17bc701ee16183f https://doi.org/10.2337/diabetes.50.8.1918

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Angiotensin II Promotes Glucose-Induced Activation of Cardiac Protein Kinase C Isozymes and Phosphorylation of Troponin I

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Promotes Glucose-Induced Activation of Cardiac Protein Kinase C Isozymes and Phosphorylation of Troponin I

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider