Population
Rat immortalized renal proximal tubular cells (IRPTCs) cultured in monolayer
Comparison
High levels of glucose and phorbol 12-myristate… vs Negative control inhibitor, D-sorbitol, or…
Design
Preclinical
Authors
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p38 MAPK links high glucose to angiotensinogen in renal cells; hypothesis-generating for diabetic nephropathy therapies.
High glucose stimulates angiotensinogen gene expression in rat kidney proximal tubular cells via a p38 MAPK-dependent, protein kinase C-independent pathway.
Zhang et al. (2000) studied this question.
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