Key result
High glucose stimulates angiotensinogen gene expression in rat kidney proximal tubular cells via reactive oxygen species generation and subsequent p38 MAPK activation.
Population
Rat immortalized renal proximal tubular cells (IRPTCs) cultured in monolayer
Design
Preclinical
Authors
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No immediate clinical implications from rat cell data; leaves open ROS-p38 MAPK pathway as therapeutic target in diabetic nephropathy.
High glucose stimulates angiotensinogen gene expression in renal proximal tubular cells via reactive oxygen species generation and p38 MAPK activation.
Hsieh et al. (2002) studied this question. High glucose was evaluated on Angiotensinogen (ANG) gene expression, ROS generation, and p38 MAPK phosphorylation. High glucose stimulates angiotensinogen gene expression in rat kidney proximal tubular cells via reactive oxygen species generation and subsequent p38 MAPK activation.
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