Key result
High glucose stimulates angiotensinogen gene expression and immortalized renal proximal tubular cell hypertrophy, mediated at least in part via activation of the hexosamine biosynthesis pathway.
Why the study?
Does activation of the hexosamine biosynthesis pathway mediate high glucose-induced angiotensinogen gene expression and cell hypertrophy in rat kidney proximal tubular cells?
Population
Immortalized renal proximal tubular cells (IRPTC) from rats cultured in monolayer
Comparison
High glucose and glucosamine, with or without… vs Normal glucose (5 mM) medium
Design
Preclinical
Authors
Loading...
Hypothesis-generating for hexosamine pathway in diabetic tubular hypertrophy; no clinical implications from this animal study.
Does activation of the hexosamine biosynthesis pathway mediate high glucose-induced angiotensinogen gene expression and cell hypertrophy in rat kidney proximal tubular cells?
High glucose stimulates angiotensinogen gene expression and renal proximal tubular cell hypertrophy at least in part via activation of the hexosamine biosynthesis pathway.
Hsieh et al. (2003) studied High glucose effect on angiotensinogen gene expression and cell hypertrophy. High glucose and glucosamine vs. Normal glucose (5 mM) was evaluated on Angiotensinogen (ANG) gene expression and cell hypertrophy. High glucose stimulates angiotensinogen gene expression and immortalized renal proximal tubular cell hypertrophy, mediated at least in part via activation of the hexosamine biosynthesis pathway.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: