Why the study?
Does RAS blockade inhibit the stimulatory effect of high glucose on ANG gene expression and hypertrophy in rat proximal tubular cells?
Population
Immortalized rat proximal tubular cells (IRPTC) cultured in monolayer
Comparison
Renin-angiotensin system blockade using… vs High glucose alone or with Ang II-receptor blocker
Design
Preclinical
Authors
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Supports intrarenal RAS mediation of tubular hypertrophy; extends in vitro data but leaves clinical translation open.
Does RAS blockade inhibit the stimulatory effect of high glucose on ANG gene expression and hypertrophy in rat proximal tubular cells?
RAS blockade effectively inhibits hyperglycemia-induced ANG gene expression and hypertrophy in rat proximal tubular cells, suggesting a role for local intrarenal Ang II in early diabetic renal hypertrophy.
Zhang et al. (2001) studied this question.
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