Key result
Left-sided adjuvant breast radiation was not associated with an increased risk of hospitalization for ischemic heart disease compared to right-sided radiation (HR 1.05; 95% CI 0.94-1.16).
Why the study?
Does adjuvant radiotherapy for left-sided breast cancer increase the risk of hospitalization for cardiac morbidity compared to right-sided breast cancer in women with nonmetastatic breast cancer?
Cohort (n=16,270)
Yes
Does adjuvant radiotherapy for left-sided breast cancer increase the risk of hospitalization for cardiac morbidity compared to right-sided breast cancer in women with nonmetastatic breast cancer?
Hazard Ratio: 1.05 (95% CI 0.94–1.16)
Absolute Event Rate: 9.9% vs 9.7%
Modern adjuvant radiotherapy for left-sided breast cancer does not appear to increase the risk of cardiac morbidity compared to right-sided breast cancer over a mean follow-up of 9.5 years.
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No increased IHD hospitalization risk with left-sided radiation in this cohort; leaves open cardiac effects of modern techniques in longer-term survivors.
Patt et al. (2005) conducted a cohort in Nonmetastatic breast cancer (n=16,270). Left-sided breast radiation vs. Right-sided breast radiation was evaluated on Hospitalization for ischemic heart disease (HR 1.05, 95% CI 0.94-1.16). Left-sided adjuvant breast radiation was not associated with an increased risk of hospitalization for ischemic heart disease compared to right-sided radiation (HR 1.05; 95% CI 0.94-1.16).
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