What question did this study set out to answer?

To evaluate long-term cardiac mortality and morbidity in patients with early-stage breast cancer following breast-conservation radiation therapy.

August 15, 2006Journal of Clinical OncologyOpen Access

Late Cardiac Mortality and Morbidity in Early-Stage Breast Cancer Patients After Breast-Conservation Treatment

View Full Paper

Ask AI

Bookmark

Why the study?

Does left-sided breast irradiation increase cardiac mortality and morbidity compared to right-sided breast irradiation in patients with early-stage breast cancer?

Population

961 consecutive patients presenting between 1977 and 1994 with stage I or II breast cancer treated with…

Comparison

Left-sided breast irradiation vs Right-sided breast irradiation

Design

Cohort

Follow-up

median 12 years

Authors

EHEleanor HarrisSt. Luke's University Health Network CCCandace R. CorreaChinese Academy of Medical Sciences & Peking Union Medical College WHWei‐Ting HwangCalifornia University of Pennsylvania

Discussion

Member takes

Implication

Higher cardiac morbidity without mortality difference in left-sided irradiation; leaves open whether modern techniques alter risk in prospective cohorts.

Key Points

To evaluate long-term cardiac mortality and morbidity in patients with early-stage breast cancer following breast-conservation radiation therapy.
Retrospective cohort analysis of 961 consecutive patients with stage I or II breast cancer treated with breast-conservation therapy between 1977 and 1994.
Tracked baseline characteristics, tumor features, and subsequent cardiac and cancer events over a median follow-up of 12 years.
Overall cardiac mortality did not differ significantly between cohorts (2% right-sided vs 3.5% left-sided; P = .25), with a 20-year cumulative risk of 6.4% (95% CI, 3.5% to 11.5%) for left-sided versus 3.6% (95% CI, 1.8% to 7.2%) for right-sided patients.
Left-sided breast irradiation was associated with significantly higher rates of chest pain, coronary artery disease, and myocardial infarction (all P ≤ .002).
Hypertension was identified as a contributing factor associated with an elevated risk of coronary artery disease among patients treated with left-sided radiation.

Structured PICO

Does left-sided breast irradiation increase cardiac mortality and morbidity compared to right-sided breast irradiation in patients with early-stage breast cancer?

Population

961 consecutive patients presenting between 1977 and 1994 with stage I or II breast cancer treated with breast conservation treatment

Intervention

Left-sided breast irradiation

Comparator

Right-sided breast irradiation

Outcome

Overall mortality from any cardiac causehard clinical

Left-sided breast irradiation for early-stage breast cancer is associated with an increased risk of coronary artery disease and myocardial infarction compared to right-sided treatment, highlighting the need for cardiovascular monitoring in this population.

Cite This Study

Harris et al. (2006) studied this question.

synapsesocial.com/papers/6a7fb31e138fa0ec199feb61 https://doi.org/10.1200/jco.2005.05.1037

Topics

Coronary artery disease Women and heart disease

View Full Paper

Ask AI

Bookmark

Implication

Higher cardiac morbidity without mortality difference in left-sided irradiation; leaves open whether modern techniques alter risk in prospective cohorts.

Late Cardiac Mortality and Morbidity in Early-Stage Breast Cancer Patients After Breast-Conservation Treatment

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Late Cardiac Mortality and Morbidity in Early-Stage Breast Cancer Patients After Breast-Conservation Treatment

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider