Why the study?
A method was needed to discriminate between necrotic permanent lesions and reversible injury associated with recurrence after atrial fibrillation ablation, evaluated using non-contrast-enhanced MRI of acute RFA lesions in the LA and PV ostia.
Does non-contrast-enhanced T1-weighted MRI (TWILITE) accurately detect acute radio-frequency ablation lesions in the left atrium and pulmonary vein ostia in a swine model?
Comparison
Non-contrast 3D TWILITE MRI sequence vs contrast-enhanced and T2-weighted imaging
Design
Preclinical animal validation study
Follow-up
2–3 mo
Authors
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Supports non-contrast MRI for acute RFA lesion detection in swine; leaves open human translation for AF ablation guidance.
Does non-contrast-enhanced T1-weighted MRI (TWILITE) accurately detect acute radio-frequency ablation lesions in the left atrium and pulmonary vein ostia in a swine model?
Non-contrast-enhanced TWILITE MRI accurately detects acute permanent radio-frequency ablation lesions in a swine model, offering a potential tool for intra- or post-procedural assessment without contrast agents.
Guttman et al. (2019) studied this question.
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