Key result
Intracoronary injection of acetylcholine and ergonovine showed no significant difference in the overall incidence of provoked coronary artery spasm (33% vs 32%, NS).
Why the study?
Does intracoronary acetylcholine compare to ergonovine in the efficacy of inducing coronary artery spasm in patients with <50% stenosis?
Population
171 patients with <50% coronary stenosis undergoing cardiac catheterization
Comparison
Intracoronary acetylcholine in incremental doses vs Intracoronary ergonovine administered 10 minutes…
Design
Cohort
Authors
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Either agent may suit spasm provocation testing; leaves open optimal choice by spasm morphology.
Does intracoronary acetylcholine compare to ergonovine in the efficacy of inducing coronary artery spasm in patients with <50% stenosis?
Absolute Event Rate: 33% vs 32%
p-value: p=NS
Intracoronary acetylcholine and ergonovine are equally effective for provoking coronary artery spasm, though they may induce different spasm morphologies (diffuse vs focal).
Sueda et al. (2003) studied Suspected coronary artery spasm with <50% stenosis (n=171). Intracoronary acetylcholine vs. Intracoronary ergonovine was evaluated on Incidence of provoked coronary artery spasm (≥99% luminal narrowing) (p=NS). Intracoronary injection of acetylcholine and ergonovine showed no significant difference in the overall incidence of provoked coronary artery spasm (33% vs 32%, NS).