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July 1, 2004Angiology

Frequency of Provoked Coronary Spasms in Patients Undergoing Coronary Arteriography Using a Spasm Provocation Test Via Intracoronary Administration of Ergonovine

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Key result

Intracoronary administration of ergonovine provoked coronary vasospasms in 29.0% of Japanese patients undergoing coronary angiography, with higher rates in those with ischemic heart disease.

Population

596 consecutive Japanese patients undergoing coronary angiography (mean age 64.2 +/- 10.3 years, 369 men).

Design

Cohort

Authors

SSShozo SuedaHKHiroaki KohnoHFHiroshi Fukuda

Discussion

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Overview

Incidence of intracoronary ER spasms higher than prior IV reports; leaves open optimal protocol and applicability outside Japanese cohorts.

Study Design

Type

Observational (n=596)

Structured PICO

P
Population
596 Japanese patients (mean age 64.2 years, 38.1% female) undergoing coronary angiography who were evaluated with a selective intracoronary ergonovine provocation test.
E
Exposure
Intracoronary administration of ergonovine (40 microg into the right coronary artery and 64 microg into the left coronary artery).
O
Outcome
Incidence of provoked coronary spasms (defined as a total or subtotal occlusion).surrogate

Intracoronary ergonovine provocation is a safe test that reveals a high incidence of coronary vasospasm in Japanese patients, particularly those with rest angina or significant atherosclerotic lesions.

Cite This Study

Sueda et al. (2004) conducted an observational in Patients undergoing coronary angiography (n=596). Intracoronary administration of ergonovine was evaluated on Incidence of provoked coronary arterial spasms (defined as total or subtotal occlusion). Intracoronary administration of ergonovine provoked coronary vasospasms in 29.0% of Japanese patients undergoing coronary angiography, with higher rates in those with ischemic heart disease.

synapsesocial.com/papers/6a6cb5ab53da1ffdb5078783https://doi.org/10.1177/000331970405500407
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Induction of coronary artery spasm by a direct local action of ergonovine.1987 · 173 citations
  2. 2Clinical impact of selective spasm provocation tests: comparisons between acetylcholine and ergonovine in 1508 examinations2004 · 87 citations
  3. 3Induction of coronary artery spasm by two pharmacological agents: comparison between intracoronary injection of acetylcholine and ergonovine2003 · 72 citations
  4. 4Coronary Artery Spasm: Use of Ergonovine in Diagnosis *1980 · 12 citations
  5. 5Frequency of provoked coronary arterial spasm in 1089 consecutive patients undergoing coronary arteriography.1982 · 503 citations