Key result
Pretreatment with oxidized LDL significantly reduced acetylcholine-mediated maximal relaxation of rabbit aortic segments compared with control (72.0% vs 94.1%, P<0.01).
Population
Rabbit aortic segments and LDL isolated from 12 healthy human subjects
Comparison
Pretreatment with oxidized LDL or specific… vs Pretreatment with native LDL or control segments…
Design
Preclinical
Authors
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Oxysterols may mediate endothelial dysfunction in atherosclerosis models; hypothesis-generating for human relevance.
Absolute Event Rate: 72% vs 94.1%
p-value: p=<.01
Cholesterol derivatives in oxidized LDL, specifically 7-ketocholesterol and 7 beta-hydroxycholesterol, reduce maximal arterial relaxation, suggesting a mechanism for endothelial dysfunction in atherosclerosis.
Deckert et al. (1997) studied Healthy subjects (n=12). Oxidized LDL vs. Native LDL and Krebs' buffer was evaluated on Acetylcholine-mediated maximal relaxation (Emax) of rabbit aortic segments (p=<.01). Pretreatment with oxidized LDL significantly reduced acetylcholine-mediated maximal relaxation of rabbit aortic segments compared with control (72.0% vs 94.1%, P<0.01).
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