Key result
Low density lipoprotein acts as a growth factor and carrier for biologically active phospholipids, which in combination with hypertension may promote vascular smooth muscle cell growth and atherosclerosis.
Why the study?
Does low density lipoprotein alter growth and signaling in vascular smooth muscle cells in the context of hypertension?
Does low density lipoprotein alter growth and signaling in vascular smooth muscle cells in the context of hypertension?
This review highlights the role of LDL as a growth factor for vascular smooth muscle cells, providing a mechanistic link between hypertension, hyperlipidemia, and atherosclerosis.
May link LDL to VSMC growth in hypertension; leaves open prospective validation before clinical translation.
There is increasing evidence that hypertension promotes low density lipoprotein (LDL) transportation into the subendothelial space of the vascular wall. Vascular smooth muscle cell (VSMC) proliferation plays an important role in the development and progression of cardiovascular diseases. Recently, several studies have demonstrated that LDL acts as a classic growth factor promoting VSMC growth via mitogenic signals normally elicited by classic growth factors. The present work summarizes current nontraditional concepts regarding possible cellular mechanisms through which hypertension and LDL may promote the development of atherosclerosis. Especially addressed are the possible effects of an elevated blood pressure in combination with LDL on VSMC growth. The new research concept concerning LDL as a growth factor and carrier for biological active phospholipids such as sphingosine-1-phosphate and sphingosylphosphorylcholine may contribute to an understanding of the pathogenesis of atherosclerosis by elevated high blood pressure.
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Gouni‐Berthold et al. (2002) conducted a review in Atherosclerosis and Hypertension. Low density lipoprotein (LDL) and hypertension was evaluated. Low density lipoprotein acts as a growth factor and carrier for biologically active phospholipids, which in combination with hypertension may promote vascular smooth muscle cell growth and atherosclerosis.
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