Key result
The 2A-mediated cleavage reaction occurs within the ribosome itself, and the ribosome-translocon complex prevents downstream proteins lacking a signal sequence from entering the endoplasmic reticulum.
Population
In vitro model studying co-translational protein import and the 2A peptide of the foot-and-mouth disease virus
Design
Preclinical
Authors
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No clinical implications yet; leaves open 2A peptide applications in cardiovascular research models.
The 2A-mediated cleavage reaction of the foot-and-mouth disease virus occurs within the ribosome itself, and the ribosome-translocon complex prevents downstream proteins lacking a signal sequence from entering the endoplasmic reticulum.
Felipe et al. (2003) studied this question. 2A peptide of the foot-and-mouth disease virus was evaluated on Mechanism of polypeptide cleavage. The 2A-mediated cleavage reaction occurs within the ribosome itself, and the ribosome-translocon complex prevents downstream proteins lacking a signal sequence from entering the endoplasmic reticulum.
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