What question did this study set out to answer?

The study aims to evaluate the effects of mild psychological stress on blood pressure, heart rate, and renal function in individuals with essential hypertension.

January 1, 1981HypertensionOpen Access

Essential hypertension: abnormal renal vascular and endocrine responses to a mild psychological stimulus.

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Why the study?

Does a mild psychological stimulus elicit abnormal renal vascular and endocrine responses in patients with essential hypertension compared to normal subjects?

Population

39 subjects: 15 patients with essential hypertension and 24 normal subjects.

Comparison

Mild emotional stimulus vs Normal subjects

Design

Cross-sectional

Authors

NHNorman K. HollenbergGeneral / Preventive / Lipids GWG. H. WilliamsBrigham and Women's Hospital DADouglass F. AdamsBrigham and Women's Hospital

Discussion

Member takes

Implication

Psychological stress may provoke abnormal renal vasoconstriction in essential hypertension; this Level 4 observation leaves open its pathogenic role and clinical relevance.

Key Points

The study aims to evaluate the effects of mild psychological stress on blood pressure, heart rate, and renal function in individuals with essential hypertension.
Assessed 24 normal subjects and 15 patients with essential hypertension using nonverbal IQ test as a psychological stimulus.
Measured arterial blood pressure, heart rate, renal blood flow, plasma renin activity, and plasma aldosterone concentration.
Analyzed differences in responses between hypertensive patients and normal subjects, including family history of hypertension.
Arterial blood pressure increased by 7 mm Hg or more in 11 of 15 hypertensives versus 3 of 16 normals (x2 = 7.23, p < 0.01).
Renal blood flow decreased in all hypertensive patients while increasing in 11 of 16 normal subjects (x2 = 15.1, p < 0.005).
Plasma renin activity rose in 14 of 15 hypertensive patients and fell in 10 of 16 normal subjects with negative family history (p < 0.005).

Structured PICO

Does a mild psychological stimulus elicit abnormal renal vascular and endocrine responses in patients with essential hypertension compared to normal subjects?

Population

39 subjects: 15 patients with essential hypertension and 24 normal subjects (8 of whom had a parent with hypertension).

Intervention

Mild emotional stimulus (a nonverbal IQ test, Raven's Progressive Matrices)

Comparator

Normal subjects (with and without a family history of hypertension)

Outcome

Changes in arterial blood pressure, heart rate, renal blood flow, plasma renin activity (PRA), and plasma aldosterone concentrationsurrogate

Patients with essential hypertension exhibit abnormal, sustained reductions in renal blood flow and increases in plasma renin activity in response to mild psychological stress.

Cite This Study

Hollenberg et al. (1981) studied this question.

synapsesocial.com/papers/6a22e8da46d2b2b483f2e2b6 https://doi.org/10.1161/01.hyp.3.1.11

Topics

Hypertension management

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Implication

Psychological stress may provoke abnormal renal vasoconstriction in essential hypertension; this Level 4 observation leaves open its pathogenic role and clinical relevance.

Essential hypertension: abnormal renal vascular and endocrine responses to a mild psychological stimulus.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Essential hypertension: abnormal renal vascular and endocrine responses to a mild psychological stimulus.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider