Clinical predictors of the rapid progression and revascularization of coronary non-target lesions: a serial angiographic study

Rapid progression of coronary no-target lesions is essential for the induction of future cardiovascular events. We aimed to investigate clinical predictors of rapid progression and revascularization of coronary non-target lesions. Consecutive patients who underwent two serial coronary angiographies were included. All coronary non-target lesions were recorded and evaluated at both procedures. A total of 1255 patients and 1670 lesions were included. At the patient level, 239 (19%) had rapid progression and 186 (14.8%) underwent revascularization. The incidence of lesion revascularization and myocardial infarction was significantly higher in patients with rapid progression. In multivariable analyses, hypertension (hazards ratio [HR], 0.76; 95% confidence interval [CI], 0.58-1.00; P = 0.049), ST-segment elevation myocardial infarction (HR, 1.46; 95%CI, 1.03-2.07; P = 0.035), glycosylated hemoglobin (HR, 1.16; 95%CI, 1.01-1.33; P = 0.039) and lesion classification (B2/C versus A/B1) (HR, 1.73; 95%CI, 1.27-2.35; P = 0.001) were significant factors associated with rapid progression. The level of triglyceride (HR, 1.10; 95%CI, 1.00-1.20; P = 0.040) and lesion classification (B2/C versus A/B1) (HR, 1.53; 95%CI, 1.09-2.14; P = 0.014) were predictors of lesion revascularization. Clinicians should pay more attention to patients with these factors to prevent future cardiovascular events.