Key result
Verapamil reduced systolic blood pressure by 8.8 mm Hg (95% CI 2.4-15.0) in black and 19.1 mm Hg in white diabetics, while metoprolol had little effect in black patients.
Why the study?
Does verapamil or metoprolol improve blood pressure differently in black compared with white diabetic patients with hypertension?
RCT (n=39)
Double blind
random order crossover
No
Does verapamil or metoprolol improve blood pressure differently in black compared with white diabetic patients with hypertension?
Verapamil is more effective than metoprolol for treating hypertension in diabetic patients, though both drugs are less effective in black patients compared to white patients.
Verapamil may be preferred to metoprolol for hypertension in black diabetics; extends evidence of racial differences in beta-blocker response.
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Cruickshank et al. (1988) conducted an RCT in Hypertension in non-insulin dependent diabetics (n=39). Verapamil and Metoprolol vs. Placebo was evaluated on Changes in blood pressure. Verapamil reduced systolic blood pressure by 8.8 mm Hg (95% CI 2.4-15.0) in black and 19.1 mm Hg in white diabetics, while metoprolol had little effect in black patients.
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