Key result
Arterial hypertension, together with an elevation in plasma aldosterone, contributes to reactive myocardial fibrosis and impaired diastolic function in experimental models.
Population
Experimental models of arterial hypertension (nonhuman primate and rat with renovascular hypertension)
Design
Review
Authors
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Hypertension plus aldosterone elevation drives fibrosis and diastolic impairment in models; extends preclinical data but leaves clinical translation open.
This review highlights that arterial hypertension and elevated aldosterone drive reactive myocardial fibrosis and diastolic dysfunction in experimental models.
Weber et al. (1991) conducted a review in Myocardial fibrosis and arterial hypertension. Arterial hypertension and elevated plasma aldosterone vs. Normotensive controls was evaluated on Myocardial fibrosis. Arterial hypertension, together with an elevation in plasma aldosterone, contributes to reactive myocardial fibrosis and impaired diastolic function in experimental models.
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