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July 1, 2007Journal of Clinical HypertensionOpen Access

Mechanisms of Cardiac Fibrosis in Hypertension

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Population

Hypertensive patients with left ventricular hypertrophy (hypertensive heart disease)

Design

Review

Authors

JDJavier Dı́ez

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Overview

Informs potential antifibrotic targets in hypertensive heart disease; leaves open prospective trials before clinical adoption.

Structured PICO

P
Population
Hypertensive patients with left ventricular hypertrophy (hypertensive heart disease)

This review highlights the mechanical, neurohormonal, and cytokine mechanisms driving myocardial fibrosis in hypertensive heart disease, which contributes to heart failure.

Cite This Study

Javier Dı́ez (2007) studied this question.

synapsesocial.com/papers/69d5721c75589c71d767e4ebhttps://doi.org/10.1111/j.1524-6175.2007.06626.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical aspects of hypertensive myocardial fibrosis2001 · 131 citations
  2. 2Regulatory Mechanisms of Myocardial Hypertrophy and Fibrosis: Results of in vivo Studies2008 · 40 citations
  3. 3Myocardial fibrosis in hypertensive heart disease: an overview of potential regulatory machanisms1995 · 71 citations
  4. 4Pathologic Hypertrophy with Fibrosis: The Structural Basis for Myocardial Failure1992 · 90 citations
  5. 5Structural remodeling in hypertensive heart disease and the role of hormones.1994 · 233 citations