Key result
Compared to HbA1c 5.0-5.4%, both low (<5.0%) and high (≥6.5%) HbA1c levels increased CVD risk in adults without known diabetes (HR 1.50, 95% CI 1.15-1.95 and HR 1.77, 95% CI 1.32-2.38).
Why the study?
Are low and high HbA1c levels associated with an increased risk of cardiovascular disease in a general population without known diabetes?
Population
29,059 adults aged 46-80 years old, free of cardiovascular disease and cancer at baseline, without known…
Comparison
Low and high HbA1c levels vs HbA1c levels of 5.0 to 5.4% (31-36 mmol/mol)
Design
Cohort
Follow-up
median 9.4 years
Authors
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HbA1c extremes were associated with higher CVD risk in non-diabetics; extends observational data but leaves open need for interventional trials.
Cohort (n=29,059)
Are low and high HbA1c levels associated with an increased risk of cardiovascular disease in a general population without known diabetes?
Hazard Ratio: 1.5 (95% CI 1.15–1.95)
p-value: p=<0.001
Both low (<5.0%) and high (≥6.5%) HbA1c levels are associated with an increased risk of cardiovascular disease in individuals without known diabetes, demonstrating a U-shaped relationship.
Goto et al. (2015) conducted a cohort in Without known diabetes (n=29,059). Low (<5.0%) and high (≥6.5%) HbA1c levels vs. HbA1c levels of 5.0 to 5.4% was evaluated on Cardiovascular disease (CVD) events (HR 1.50, 95% CI 1.15-1.95, p=<0.001). Compared to HbA1c 5.0-5.4%, both low (<5.0%) and high (≥6.5%) HbA1c levels increased CVD risk in adults without known diabetes (HR 1.50, 95% CI 1.15-1.95 and HR 1.77, 95% CI 1.32-2.38).
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