Key result
Vinculin is localized just beneath the plasma membrane of the neuromuscular junction, with 50% of the label within 30 nm from the cytoplasmic side, potentially anchoring filament meshworks.
Population
Fresh, unfixed muscles (neuromuscular junctions)
Design
Preclinical
Authors
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No immediate clinical implications; extends ultrastructural mapping of vinculin in animal neuromuscular junctions.
Vinculin is localized just beneath the plasma membrane at the neuromuscular junction, suggesting a role in anchoring cytoskeletal meshworks.
Yorifuji et al. (1989) studied this question. Vinculin is localized just beneath the plasma membrane of the neuromuscular junction, with 50% of the label within 30 nm from the cytoplasmic side, potentially anchoring filament meshworks.
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