Why the study?
Do statins promote regression or stabilization of atherosclerosis?
Do statins promote regression or stabilization of atherosclerosis?
The paper reviews evidence on statin-induced atherosclerosis regression and introduces the rationale and baseline characteristics of the Russian FREGAT study.
May support statin consideration for carotid plaque stabilization; leaves open confirmation from FREGAT trial results.
Atherosclerosis and it’s clinical implications (myocardial infarction, stroke, intermittent lameness) is a serious medico-social problem in Russia. Statins (or HMG-CoA reductase inhibitors) are the first-choice agents to prevent cardiovascular disease events. The paper presents the results of early regression studies and modern regression studies using MRI imaging concerning the regression or stabilization atherosclerosis and rationale and baseline characteristics of russian regression study “FREGAT”.
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Лугинова et al. (2015) studied this question.
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