Key result
Insulin enhances myocardial blood flow and decreases coronary vascular resistance, which may contribute to the beneficial effects of GIK therapy during acute myocardial ischemia.
Design
Review
Authors
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Insulin's acute coronary vasodilation may aid ischemia; leaves open GIK net benefit amid chronic hyperinsulinemia risks.
Insulin has acute vasodilatory effects that may benefit myocardial ischemia, but chronic hyperinsulinemia acts as an independent risk factor for coronary artery disease.
Jari Sundell (2003) conducted a review in Acute myocardial infarction and coronary artery disease. Insulin / glucose-insulin-potassium infusion (GIK) was evaluated. Insulin enhances myocardial blood flow and decreases coronary vascular resistance, which may contribute to the beneficial effects of GIK therapy during acute myocardial ischemia.
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