Key result
Chronic alcohol abuse was associated with significantly impaired flow-mediated vasodilation compared to healthy controls (6.03% vs 13.7%; P<.05).
Why the study?
Does chronic alcohol abuse impair endothelial-dependent vasodilatation and cardiac function in patients without other cardiovascular risk factors?
Population
40 subjects: 20 alcoholics without coexisting conditions after a 3-month period of abstinence, and 20…
Comparison
Chronic alcohol abuse vs Alcohol-free healthy subjects
Design
Case-control
Authors
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May warrant vascular monitoring in abstinent alcoholics without other risks; leaves open causal role in CVD.
Case-Control (n=40)
Does chronic alcohol abuse impair endothelial-dependent vasodilatation and cardiac function in patients without other cardiovascular risk factors?
Absolute Event Rate: 6.03% vs 13.7%
p-value: p=<.05
Chronic alcohol abuse is associated with impaired endothelial-dependent vasodilatation and diastolic dysfunction even after 3 months of abstinence, potentially contributing to excess cardiovascular disease.
Giuseppe Maiorano (1999) conducted a case-control in Chronic alcohol abuse (n=40). Chronic alcohol abuse vs. Alcohol-free healthy subjects was evaluated on Brachial artery flow-mediated vasodilation (FMD) (% diameter change) (p=<.05). Chronic alcohol abuse was associated with significantly impaired flow-mediated vasodilation compared to healthy controls (6.03% vs 13.7%; P<.05).
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