Key result
Relatively low wall shear stress in the mouse aorta is associated with increased expression of VCAM-1 and ICAM-1, mirroring atherosclerotic plaque localization in humans.
Relative differences or direction of wall shear stress, rather than absolute magnitude, may be the relevant determinants of flow-mediated inflammatory responses and atherogenesis in mouse models.
No takes yet. Share an insight, caveat, or question.
Low WSS links to VCAM-1/ICAM-1 upregulation in mice; leaves open whether absolute thresholds drive human plaque localization.
Suo et al. (2006) studied Atherosclerosis. Wall shear stress (WSS) was evaluated on Wall shear stress values and expression of VCAM-1 and ICAM-1. Relatively low wall shear stress in the mouse aorta is associated with increased expression of VCAM-1 and ICAM-1, mirroring atherosclerotic plaque localization in humans.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: