What does this research mean for the field?

Aortic arch geometry differs significantly between 129/SvEv and C57BL/6 mice, resulting in lower wall shear stress at the inner curvature in 129/SvEv mice that corresponds to greater local atherosclerotic plaque involvement. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

September 4, 2009Journal of Biomechanical EngineeringOpen Access

Differences in Aortic Arch Geometry, Hemodynamics, and Plaque Patterns Between C57BL/6 and 129/SvEv Mice

Q: What are the key findings of this study?

Aortic arch geometry differed significantly between 129/SvEv and C57BL/6 mice (p<0.05), with lower shear stress at the inner curvature in the 129 strain corresponding to greater plaque involvement.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Atherosclerosis susceptibility (n=14). Intervention: 129/SvEv mouse strain vs. C57BL/6 mouse strain. Primary outcome: Aortic arch geometry (shape, vessel diameter, branch locations) and hemodynamic wall shear stress (p=<0.05).

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Key result

Lower aortic arch shear stress links to greater plaque involvement in 129/SvEv mice.

P<0.05
n=14

Authors

HZHui ZhuShanghai University of Engineering Science JZJi ZhangChina University of Mining and Technology JSJessica G. ShihSunnybrook Health Science Centre

Discussion

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Implication

Mouse strain differences in aortic geometry modulate WSS; leaves open translation to human plaque localization.

PICO

Population

14 murine aortic arches (7 from C57BL/6 and 7 from 129/SvEv wild-type mice) analyzed for 3D geometry and hemodynamic wall shear stress.

Exposure / Comparator

129/SvEv mouse strain vs C57BL/6 mouse strain

Primary Outcome

Aortic arch geometry (shape, vessel diameter, branch locations) and hemodynamic wall shear stress, p=<0.05

Main Result

p-value: p=<0.05

Cite This Study

Zhu et al. (2009) studied Atherosclerosis susceptibility (n=14). 129/SvEv mouse strain vs. C57BL/6 mouse strain was evaluated on Aortic arch geometry (shape, vessel diameter, branch locations) and hemodynamic wall shear stress (p=<0.05). Aortic arch geometry differed significantly between 129/SvEv and C57BL/6 mice (p<0.05), with lower shear stress at the inner curvature in the 129 strain corresponding to greater plaque involvement.

synapsesocial.com/papers/6aa83bd81105cc3e82cece87 https://doi.org/10.1115/1.4000168

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Differences in Aortic Arch Geometry, Hemodynamics, and Plaque Patterns Between C57BL/6 and 129/SvEv Mice

Discussion

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Implication

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Main Result

Cite This Study

Differences in Aortic Arch Geometry, Hemodynamics, and Plaque Patterns Between C57BL/6 and 129/SvEv Mice

Discussion

Member takes

Implication

PICO

Main Result

Cite This Study

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