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July 6, 2005Nuclear Medicine Communications

The feasibility of repeated left ventricular ejection fraction analysis with sequential single-dose radionuclide ventriculography

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Key result

Repeated planar radionuclide ventriculography within 3 hours using a single 500 MBq dose of [Tc]pertechnetate showed excellent reproducibility for LVEF (mean difference 0.94%; 95% CI -2.7 to 4.5).

Why the study?

Does repeated planar radionuclide ventriculography within 3 hours using a single standard dose of [Tc]pertechnetate provide reproducible LVEF measurements in patients?

Population

16 patients undergoing routine planar radionuclide ventriculography

Comparison

Repeat planar radionuclide ventriculography… vs Initial planar radionuclide ventriculography…

Design

Cohort

Follow-up

3 hours

Authors

PVPieter A. van der VleutenRSRiemer H. J. A. SlartRTRené A. Tio

Discussion

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Overview

Supports single-dose repeat LVEF imaging feasibility in small cohorts; leaves open larger prospective validation before clinical adoption.

Study Design

Type

Observational (n=16)

Structured PICO

Does repeated planar radionuclide ventriculography within 3 hours using a single standard dose of [Tc]pertechnetate provide reproducible LVEF measurements in patients?

P
Population
16 patients undergoing routine planar radionuclide ventriculography with a repeat scan after 3 hours.
E
Exposure
Repeat planar radionuclide ventriculography after 3 hours without administration of additional tracer
C
Comparator
Initial planar radionuclide ventriculography with a standard dose of 500 MBq of [Tc]pertechnetate
O
Outcome
Reproducibility of LVEF measurementsurrogate

Main Result

Mean Difference: 0.94 (95% CI -2.7–4.5)

p-value: p=NS

Repeated radionuclide ventriculography with a 3-hour interval using a single standard dose of 500 MBq of [Tc]pertechnetate is highly reproducible for LVEF measurement.

Cite This Study

Vleuten et al. (2005) reported an observational. Repeated planar radionuclide ventriculography vs. Initial planar radionuclide ventriculography was evaluated on Mean LVEF difference between baseline and repeat planar radionuclide ventriculography (MD 0.94, 95% CI -2.7 to 4.5, p=NS). Repeated planar radionuclide ventriculography within 3 hours using a single 500 MBq dose of [Tc]pertechnetate showed excellent reproducibility for LVEF (mean difference 0.94%; 95% CI -2.7 to 4.5).

synapsesocial.com/papers/6a22fd5ace88d8ac62d26eeehttps://doi.org/10.1097/01.mnm.0000172742.44111.6d
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance. Are they interchangeable?2000 · 1,054 citations
  2. 2Quantitative and Qualitative Assessment of Left Ventricular Volume with Ecg-Gated Multislice Spiral Ct: Value of Different Image Reconstruction Algorithms in Comparison to MRI2003 · 90 citations
  3. 3A Noninvasive Scintiphotographic Method for Detecting Regional Ventricular Dysfunction in Man1971 · 214 citations
  4. 4Breath-hold FLASH and FISP Cardiovascular MR Imaging: Left Ventricular Volume Differences and Reproducibility2002 · 296 citations
  5. 5Cardiac Function at Rest and During Exercise in Normals and in Patients with Coronary Heart Disease1978 · 287 citations