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November 1, 2018Biochemistry and Biophysics ReportsOpen Access

The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C

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Authors

MLMonica X. LiUniversity of AlbertaSGShorena GeloziaUniversity of AlbertaGDGaddafi I. DanmalikiUniversity of Alberta

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Implication

MCI-154 effects likely troponin-independent; leaves open alternative cardiac targets for further mechanistic study.

Key Points

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Cite This Study

Li et al. (2018) studied this question.

synapsesocial.com/papers/6a22fdd99135d99b72cb1e48https://doi.org/10.1016/j.bbrep.2018.10.012
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Binding of Cardiac Troponin-I<sub>147-163</sub> Induces a Structural Opening in Human Cardiac Troponin-C<sup>,</sup>1999 · 259 citations
  2. 2The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C2014 · 61 citations
  3. 3β‐adrenergic receptor signalling and its functional consequences in the diseased heart2016 · 114 citations
  4. 4High Selectivity for Inhibition of Phosphodiesterase III and Positive Inotropic Effects of MCI-154 in Guinea Pig Myocardium1993 · 24 citations