Key result
F-actin inhibits ADP binding to myosin and its fragments, but significant ADP binding remains even at saturating actin concentrations, suggesting distinct but interacting binding sites.
Authors
Loading...
Should not inform cardiac myosin therapies; extends models of distinct yet interacting ADP-actin sites.
Beinfeld et al. (1975) studied this question. F-actin was evaluated on ADP binding to myosin, heavy meromyosin, and subfragment 1. F-actin inhibits ADP binding to myosin and its fragments, but significant ADP binding remains even at saturating actin concentrations, suggesting distinct but interacting binding sites.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: