Key result
Actin binds to myosin subfragment 1 and ADP in a two-step reaction, accelerating the release of product from the A.M.D state, which may help maintain tension with a low ATP turnover rate.
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Hypothesis-generating for cross-bridge kinetics; leaves open relevance to intact cardiac muscle function.
Michael A. Geeves (1989) studied this question. Actin, myosin subfragment 1 (S1), and ADP was evaluated on Equilibrium and dynamics of the interaction between actin, myosin subfragment 1 (S1), and ADP. Actin binds to myosin subfragment 1 and ADP in a two-step reaction, accelerating the release of product from the A.M.D state, which may help maintain tension with a low ATP turnover rate.
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