January 15, 1991Biochemistry

Kinetics of the interaction of 2'(3')-O-(N-methylanthraniloyl)-ATP with myosin subfragment 1 and actomyosin subfragment 1: Characterization of two acto.cntdot.S1.cntdot.ADP complexes

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Population

Myosin subfragment 1 (S1) and actomyosin subfragment 1 (acto-S1) in vitro model

Design

Preclinical

Authors

SWSally K. A. WoodwardUniversity of Basel JEJohn F. EcclestonMRC London Institute of Medical Sciences MGMichael A. GeevesHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

Hypothesis-generating for crossbridge kinetics; leaves open translation to intact human myocardium.

Structured PICO

Population

Myosin subfragment 1 (S1) and actomyosin subfragment 1 (acto-S1) in vitro model

Intervention

mantATP [2'(3')-O-(N-methylanthraniloyl)-adenosine 5'-triphosphate] and mantADP

Outcome

Kinetics of interaction and rate of ADP dissociationsurrogate

The use of mantATP reveals distinct kinetic states in the acto-S1 complex, providing biochemical evidence for the force-generating transition in the crossbridge cycle.

Cite This Study

Woodward et al. (1991) studied this question.

synapsesocial.com/papers/6a76faade29fd788c9f6f7f9 https://doi.org/10.1021/bi00216a017

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Kinetics of the interaction of 2'(3')-O-(N-methylanthraniloyl)-ATP with myosin subfragment 1 and actomyosin subfragment 1: Characterization of two acto.cntdot.S1.cntdot.ADP complexes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Kinetics of the interaction of 2'(3')-O-(N-methylanthraniloyl)-ATP with myosin subfragment 1 and actomyosin subfragment 1: Characterization of two acto.cntdot.S1.cntdot.ADP complexes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider