Key result
Partial left ventriculectomy for terminal heart failure yielded highly variable mortality ranging from 0% to 60%, with no reliable predictors of postoperative outcome identified.
Why the study?
Does partial left ventriculectomy improve outcomes and symptoms in patients with terminal heart failure?
Observational (n=465)
Does partial left ventriculectomy improve outcomes and symptoms in patients with terminal heart failure?
Partial left ventriculectomy for terminal heart failure provides short-term symptom relief but has highly variable mortality and fails to halt progressive ventricular dysfunction.
High outcome variability precludes routine use in terminal HF; leaves open refined patient selection for future trials.
OBJECTIVE: To identify useful predictive data on chance mechanisms of postoperative outcome, the impact on symptoms of terminal heart failure - after partial left ventriculectomies (PLV) - was critically evaluated through the analysis of results, on accumulated descriptive data on reports, between 1995 and 1998. METHOD: Available routine clinical data on surgical aspects and clinical outcomes were gathered and, when possible, validated for comparative analysis. RESULTS: PLV can provide a significant short to medium term amelioration in the quality-of-life in event-free survivors, but it was also watched out that in important proportion of them - as an evolutive sequence - PLV was incapable of changing the myocardial fibers leading tendency to conservatism of the preoperative vicious geometric dynamic pattern in late evolution. Importantly, the LV end-diastolic echocardiographic diameter of 7.5 cm (± 1.4 cm) was the steadiest quantitative significant numerical appeal to heart reduction surgery, in a setting of 465 patients, aged two to 74 years. And in a succession of individual reports of PLV results, whose mortality varied from 0 a 60%, survival after PLV showed a significant relationship with morphologic evolution of cardiomyocytes, in postoperative, and augmented in absolute values in patients with progressive ventricular dysfunction, treated with the insertion of LVAD (Left Ventricular Assist Devices). CONCLUSION: The material impossibility of identifying useful qualified predictors on chance mechanisms of postoperative outcome emerged as the crucial limitation for current usage of surgical reversal of left ventricular structural chamber dilation - to treat dilated cardiomyopathies - despite accumulated numerical values and clinical experiences.
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Christo et al. (2003) conducted an observational in Terminal heart failure (n=465). Partial left ventriculectomy was evaluated on Postoperative outcome and mortality. Partial left ventriculectomy for terminal heart failure yielded highly variable mortality ranging from 0% to 60%, with no reliable predictors of postoperative outcome identified.
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