Key result
Patients with angina, risk factors for microvascular disease, and no obstructive coronary artery disease had significantly reduced myocardial perfusion reserve compared to healthy controls (median 2.21 vs. 2.93, p < 0.001).
Why the study?
Does fully quantitative CMR perfusion imaging identify reduced myocardial perfusion reserve in patients with angina and risk factors for microvascular disease compared to healthy controls?
Population
46 patients with typical angina and risk factors for microvascular disease who had no obstructive coronary…
Comparison
Regadenoson stress cardiovascular magnetic… vs Healthy control subjects
Design
Case-control
Authors
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May aid detection of microvascular dysfunction via quantitative CMR in angina without obstructive CAD; hypothesis-generating, should not yet change practice.
Cross-Sectional (n=66)
No
Does fully quantitative CMR perfusion imaging identify reduced myocardial perfusion reserve in patients with angina and risk factors for microvascular disease compared to healthy controls?
Absolute Event Rate: 2.21% vs 2.93%
p-value: p=<0.001
Fully quantitative CMR perfusion imaging identifies reduced myocardial perfusion reserve in patients with angina and risk factors for microvascular disease, independent of myocardial hypertrophy or fibrosis.
Zorach et al. (2018) conducted a cross-sectional in Microvascular coronary artery disease (n=66). Microvascular disease risk factors without obstructive CAD vs. Healthy controls was evaluated on Myocardial perfusion reserve (MPR) (p=<0.001). Patients with angina, risk factors for microvascular disease, and no obstructive coronary artery disease had significantly reduced myocardial perfusion reserve compared to healthy controls (median 2.21 vs. 2.93, p < 0.001).
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