Key result
Chronic captopril or losartan administration improved hemodynamics, reversed cardiac hypertrophy, and restored ANF levels in rats with moderate high-output heart failure.
Why the study?
Does chronic captopril or losartan administration improve hemodynamics, reverse cardiac hypertrophy, and normalize ANF levels in rats with high-output heart failure?
Does chronic captopril or losartan administration improve hemodynamics, reverse cardiac hypertrophy, and normalize ANF levels in rats with high-output heart failure?
Chronic ACE inhibition and angiotensin II receptor antagonism improve hemodynamics and reverse cardiac hypertrophy in a rat model of high-output heart failure.
May guide preclinical high-output HF models; leaves open human translation.
We investigated the role of atrial natriuretic factor (ANF) and the renin-angiotensin system as well as the effects of losartan in rats with aortocaval (AC) shunts. Right atrial and left ventricular end-diastolic pressures (LVEDP) were higher and mean arterial blood pressure (MAP) was lower in AC shunt animals than in their controls. AC shunt rats presented marked cardiac hypertrophy, decreased right atrial ANF concentration, and increased ventricular ANF content and concentration. Plasma ANF levels were elevated, and hematocrit was lower in AC shunt animals than in controls. Captopril or losartan treatment decreased MAP and returned LVEDP to sham-operated control values. A clear regression of cardiac hypertrophy was evident in both treated AC shunt groups, with plasma ANF levels tending to follow those in sham-operated rats. Plasma COOH-terminal ANF levels were decreased and urinary volume and hematocrit were increased in losartan-treated AC shunt animals. We conclude that chronic angiotensin converting enzyme inhibition and angiotension II receptor antagonism improved hemodynamic conditions, diminished water retention, reversed cardiac hypertrophy, and restored plasma and tissue ANF to more "normal" levels in rats with moderate high-output heart failure.
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Qing et al. (1992) studied High-output heart failure. Captopril or losartan vs. Sham-operated controls and untreated AC shunt animals was evaluated on Hemodynamic conditions, cardiac hypertrophy, and ANF levels. Chronic captopril or losartan administration improved hemodynamics, reversed cardiac hypertrophy, and restored ANF levels in rats with moderate high-output heart failure.
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