Myocardial renin is neither necessary nor sufficient to initiate or maintain ventricular hypertrophy

Katz et al. (2000) studied Ventricular hypertrophy. DOCA implants and 1% NaCl drinking water, with and without losartan, or low-sodium diet was evaluated on Initiation and maintenance of ventricular hypertrophy. The myocardial renin-angiotensin system is neither necessary to initiate or maintain cardiac hypertrophy in DOCA-treated rats nor sufficient to initiate it in low-salt diet-fed rats.